Thought Leadership


These articles and clinical white papers have been written by Quanticate managers and members of the Quanticate consultancy team. Feel free to click on the titles/images to receive the articles.

Integrated Summaries of Safety and Efficacy: The Role of the Medical Writer

integrated summaries medical writer This paper looks at how a Medical Writer should contribute to the production of a quality ISS/ISE. It follows a previous white paper on the role of Statisticians and Programmers in the production of integrated summaries.

Traceability – Where is your Clinical Information?

traceability This paper outlines why sponsors of clinical trials should re-examine and plan for proper traceability of their clinical information.

Phase 1 Studies: Roles and Obligations of the Medical Writer

phase 1 studies medical writing This article outlines the support needed from medical writers during the design, conduct and reporting of Phase I studies, but also their obligations when it comes to publishing results.

Important Considerations for Clinical Development Programmes

clinical development This 8 page article on Important Considerations in Clinical Development Programmes is for anyone embarking on the development of a new medicinal product.

PK/PD Models: Reducing Phase 3 Attrition Rates

pd pk modelling This short article outlines how thorough PK/PD modelling can significantly reduce the risk of failure in Phase 3 trials.

Integrated Summaries (ISS / ISE)

ise iss In this 9 page article Quanticate outlines the issues that can arise in the planning of an Integrated Summary of Safety (ISS) and Integrated Summary of Effectiveness (ISE).

Overview of Challenges in Oncology Studies

oncology studies If you are planning an oncology study you will be aware that these studies are more complex than others. Our consultant team in Quanticate have put together an initial article that outlines the typical challenges presented by such studies and offers some recommendations to counter them.

Flexible Phase I Study Designs: Expediting Early Clinical Drug Development

phase i studies   This article outlines the considerations that need to be made at the planning stage, and how to make best use of emerging PK and safety data to enable informed decisions regarding study progression.

Clinical SAS Programming Efficiently with Large SAS Datasets

large sas datasets This 14 page article looks at SAS® programming techniques to help you program more efficiently. Size reduction techniques for large datasets are explored to give you smaller sized, faster running, more efficient programs.

Bayesian Study Design: Using Interim Analyses to Improve Efficiency in Drug Development

Bayesian study design interim analyses This second article expands on how the Bayesian framework is highly appropriate for planning and executing interim analyses in your clinical trial study design.

Bayesian Study Design: The Pragmatic Solution for Phase II Clinical Development

Bayesian study design If you are planning a Phase II study, you may find this 8 page article useful as it looks at how the Bayesian framework provides solutions for clinical development teams.

Finding The Best Value Through Well Prepared Requests for Proposals (RFPs)

clinical rfps A 3 page article on getting Request For Proposals right so that the months which follow will be much more enjoyable. The article expands on the concept of a verly clearly defined RFP being the starting point for a clinical study to run smoothly and stay within budget.

Making a CRO Project Run Smoothly

cro project   A 2 page article on the initial steps for smooth practices when embarking on new outsourcing projects. This paper touches on teething problems and helping to find the right team.

Clinical Conclusions: Producing Comprehensive Integrated Summaries

clinical conclusions This 3 page article looks at some of the areas where regulatory guidelines are lacking on the preparation of integrated summaries. It identifies some of the pitfalls (and solutions) for the unwary who need to manage the quality and cost of producing integrated summaries.

Current Trends in Pharmacovigilance

current trends pharmacovigilance A 4 page article talks about a need to improve pharmacovigilance systems to more effectively monitor and take action on safety issues associated with medicines.

Costs of Outsourcing vs Internal Deployment

outsourcing vs internal deployment   This 6 page article identifies cost factors that companies need to assess to make an informed decision on clinical outsourcing or the use internal deployment.

Benefits of Centralizing Clinical Data Services

centralizing clinical data This article looks at the advantages of centralizing those “back end” services whether it is internally by the Sponsor, with a full service CRO or with a specialist biometrics CRO.

eProposals: An Interactive Approach to eProcurement

eproposals This 7 page article discusses the benefits to all parties involved in the vendor selection process when considering eProposals.

 

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