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[Free White Paper]
Bayesian Study Design
Using Interim Analyses to Improve Efficiency in Drug Development
This second whitepaper
shows how the Bayesian framework is highly appropriate for planning and executing interim
The rationale for using a Bayesian approach to interim analyses is explained.
The formulation of interim decision rules on the basis of posterior and predictive probability is introduced and evaluated using a case study.
The value of simulations are included to assess the merits of the different decision rules and the relative timing of interim analyses is illustrated.
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