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[Free White Paper]

Bayesian Study Design

Using Interim Analyses to Improve Efficiency in Drug Development

This second whitepaper shows how the Bayesian framework is highly appropriate for planning and executing interim analyses:
  • The rationale for using a Bayesian approach to interim analyses is explained.
  • The formulation of interim decision rules on the basis of posterior and predictive probability is introduced and evaluated using a case study.
  • The value of simulations are included to assess the merits of the different decision rules and the relative timing of interim analyses is illustrated.

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