Where and when did Pharmacovigilance begin? Medical remedies have been recognized by mankind for thousands of years, and so have their potential dangers, side effects, and benefits. During the 20th century there were some serious adverse events associated with medical products and drugs that resulted in pressure on governments, businesses to produce legalization and guidance, as well as the evolution of regulatory bodies to protect the safety of patients. As this pressure arose, drug and device development companies started practicing pharmacovigilance and Clinical Research Organisations began offering pharmacovigilance services. This infographic identifies those significant milestones across the 20th century and into the modern era.